Physical symptoms of depression: 13 signs you may have it


Editorial Team


June 5, 2024

young woman with physical symptoms of depression touching neck

Most people know how emotionally taxing mental health issues can be. But what many people don’t know is that when you have depression, physical symptoms can impact you significantly. Let’s look at 13 physical symptoms of depression, why they occur, and what you can do to start feeling better.

Most people know how emotionally taxing mental health issues can be. But what many people don’t know is that when you have depression, physical symptoms can impact you significantly. Let’s look at 13 physical symptoms of depression, why they occur, and what you can do to start feeling better.

Mental health conditions like depression impact not only your mind, but can also cause physical symptoms in your body.

1. Issues with sleep

It’s common for depressive disorders to cause issues with sleep—both sleeping too much, known as hypersomnia, or too little, insomnia. People with insomnia are at increased risk for depression, and more than half of people with depression report trouble falling or staying asleep. Some researchers even believe that depression and insomnia share common neurobiology

2. Fatigue

Depression can slow your whole system down—one reason people with depression sometimes move and speak more slowly than usual, to the point that it’s noticeable to others or challenging to function. Feeling lethargic is quite common with this condition. 

There may be a reason for this. The polyvagal theory actually sees depression as a part of the human body’s biologically intelligent makeup. According to this theory, depression might be your body’s physiological response to perceived danger or defeat. 

This theory hypothesizes that depression is the same kind of survival response an animal has when it freezes or shuts down when confronted with a threat. This may contribute to some of the changes you experience with sleep and your energy level.

When you have depression, your sleep schedule may change dramatically. You may slow down in your speech, movements, and even in your mental processes. Many people experience this decrease in energy as fatigue.

3. Muscle aches 

Having depression can worsen bodily inflammation. Researchers have demonstrated that pain mediators produced in response to inflammation can induce depressive symptoms. On top of that, some studies show that depression can increase pain sensitivity, though conflicting research also exists.

According to polyvagal theory, feelings of pain—both physical and mental—may arise to keep you from expending unnecessary energy. Muscle aches and other kinds of pain may keep you from working or spending time with others. 

4. Joint pain

Vague aches and pains can be some of the first symptoms of depression. Many people seeking medical advice for joint pain and other types of physical pain only have physical symptoms, making it especially challenging to diagnose depression. 

But the relationship between pain and depression is bi-directional, meaning that depression can lead to more significant pain and that higher pain levels can bring on depression. 

Serotonin and norepinephrine are neurotransmitters that impact both pain and mood. An imbalance in these transmitters is linked to both depressed mood and the physical experience of pain.

5. Digestive issues 

Emotional stress often occurs with conditions like irritable bowel syndrome (IBS) or general gastrointestinal issues. The symptoms of these conditions include nausea, diarrhea, appetite fluctuations, and cramps. You might also experience a sinking feeling in the stomach. All of these can be interrelated with emotional stressors and mental health conditions like anxiety and depression. 

You may have heard about the brain-gut connection. The millions of nerve cells that line your gastrointestinal system can receive and send messages to your brain. Irritation or imbalance in the digestive system can impact mood, just as emotional stress can affect digestion.

6. Dizziness or lightheadedness 

Psychological conditions such as anxiety and depression can present with dizziness or lightheadedness as a symptom. Some research indicates that as many as 20% of people with dizziness experienced high levels of psychological distress.

7. Back pain 

Chronic or severe back pain puts you at risk for major depression because the stress pain causes your whole system. Especially if you’re already experiencing emotional stress, depression can magnify your thoughts and physical sensitivity to pain. In addition, increased pain, especially chronic pain, can lead to feelings of depression and hopelessness.

8. Headaches and migraines  

Depression headaches are another common physical manifestation of depressive disorders. Cluster headaches, tension headaches, and migraines are frequently reported by people experiencing depression.

9. Changes in hunger and weight

Depression can lead some people to seek comfort by eating more than usual and binge eating. For others, having depression can lead to less interest in food and a decreased appetite. Fluctuations away from your healthy baseline of appetite and weight can be related to depressive disorders. 

10. Low libido 

A key symptom of depression is anhedonia, a decreased ability to enjoy activities that are typically pleasurable. And this doesn’t just apply to your hobbies. When your body is stressed by depression, physical symptoms such as low sex drive can lead to erectile dysfunction, inability to achieve orgasm, and even a complete lack of interest in sex. Learn more about how anxiety impacts sexual arousal and functioning.

Learn more about premature ejaculation here.

11. Feeling restless and fidgety

Some people experience co-occurring symptoms of anxiety and depression, which are sometimes described as agitated depression. Instead of feeling lethargic, you may be unable to sit still. With agitated depression, you may also feel more impulsive, irritable, and restless.

12. Vision problems 

People with impaired vision are at increased risk for depression. Similarly, people who are currently depressed often report seeing the world as looking “dull” and are less perceptive to visual contrasts. And studies show that among older adults, issues with vision and vision loss are among the most common conditions associated with depression.

13. Skin reactions and disorders 

Issues with your skin, especially chronic or recurring conditions such as psoriasis or eczema, are correlated with elevated risk for certain depressive disorders. Skin issues are also a commonly occurring effect of anxiety on the body

Can depression make you sick?

Yes. The same system in your brain that moderates experiences of physical pain also moderates moods. Depression can be experienced and expressed in the mind and body as emotional, behavioral, cognitive, and physical symptoms. 

For example, when you’re feeling sad, avoiding life, and engaging in negative thinking, you may experience physical signs of depression, such as body aches and pains.   

Further, experiencing chronic pain or illness increases your risk for depression. Depression can also cause physical pains in your body. Cytokines, the immunomodulating molecules released by cells, are a bidirectional factor in both bodily inflammatory symptoms and depression.

These feedback loops can leave you feeling exhausted and drained. In fact, multiple studies have shown that the majority of people with depression report somatic or bodily symptoms

Simultaneously experiencing physical and emotional symptoms increases how unpleasant and disruptive depression is. People with more symptoms report more challenges in critical areas of life such as employment and healthy activity levels. These symptoms can also cause disruptions and difficulties in relationships.

Some studies have shown a correlation between experiencing more physical pain and longer-lasting depressive episodes. 

There’s also a high correlation between the use of alcohol and depression. Many people who have depression seek relief from its symptoms with alcohol and other substances, leading to an increased risk of addiction. Unfortunately, drinking and substance use can make mental health issues worse over time—leading some people to experience immediate effects like hangover depression or anxiety after drinking.


Many of the treatments that ease mood symptoms can also ease physical symptoms. The more ways you can increase care and treatment for your body-mind, the faster your recovery may be. Understanding what’s happening is an essential step in finding the treatments and lifestyle changes that will help you recover. 


Your healthcare provider may recommend antidepressant medications that impact norepinephrine and serotonin levels, neurotransmitters that facilitate communication in the brain. If you’re interested in talking with a medical professional about whether medication for depression would be a good fit for your needs, visit Lemonaid.

Identify triggers

Relatively small adjustments to your routine can reduce triggers for both depression and pain. For example, avoiding bedtime social media usage may improve sleep quality, leading to improved mood and reduced pain flare-ups. Reducing inflammatory foods in your diet might also improve mood, energy, and sleep quality.

Talk therapy

Maladaptive responses to pain can intensify and worsen the challenge. For example, catastrophizing about pain can mean you experience it for longer. Talk therapy can be a place to find support and learn new coping skills and cognitive strategies.

Take a holistic approach

The most effective treatment strategies are those that take your whole self into account. Don’t be afraid to ask your healthcare providers about their familiarity and experience with your symptoms. 

It can also be beneficial to permit or your providers to work across disciplines. When your psychiatrist, primary care doctor, and therapist can exchange and update medical information, they’re more likely to understand how to support your whole body health as a care team.  


  • Physical illness and depression are correlated and bi-directional, meaning they may share some of the same underlying processes.
  • Treatment for both depression and its physical symptoms includes medication, identifying and avoiding triggers, and talk therapy.
  • Seek out a multidisciplinary team of healthcare professionals who can help tailor your treatment to address your symptoms as well as any underlying issues.
  1. Amirir et al. (2020). Back pain and depressive symptoms: A systematic review and meta-analysis 
  2. Bair et al. (2003). Depression and pain comorbidity: a literature review 
  3. Benca & Peterson (2008). Insomnia and depression. 
  4. Dantzer (2012). Depression and inflammation: An intricate relationship 
  5. The Discovery Eye Foundation. (2015). Vision Loss and Depression 
  6. Harvard Health (2015). Nutritional psychiatry: Your brain on food.
  7. Johns Hopkins Medicine. (N.D.) The Brain-Gut Connection 
  8. Kapfhammer (2006). Somatic symptoms in depression 
  9. Kim et al. (2016). Clinical Analysis of Dizzy Patients with High Levels of Depression and Anxiety.
  10. Porgues (2009). The polyvagal theory: New insights into adaptive reactions of the autonomic nervous system 
  11. The Psychiatry and Behavioral Health Learning Network. (2019). Vision Loss Linked With Anxiety, Depression – and Vice Versa 
  12. Simon et al. (2015). An international study of the relation between somatic symptoms and depression 
  13. Trivedi (2004). The Link Between Depression and Physical Symptoms.
  14. Zhang et al. (2013). Association Between Depression and Functional Vision Loss in Persons 20 Years of Age or Older in the United States, NHANES 2005–2008.


Editorial Team


June 5, 2024

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment or medication.